Eylea Biosimilar Pavblu Enters Crowded Market With Some Uncertainty

  • Nov 14, 2024

    The first biosimilar of Regeneron Pharmaceuticals, Inc.’s Eylea (aflibercept) recently hit the U.S. market when Amgen Inc. launched Pavblu (aflibercept-ayyh). The drug is entering a crowded class that includes a compounded drug used off-label, as well as a high-dose formulation of Eylea. But it’s unclear how much both agents may be used going forward.

    A compounded formulation of Roche Group unit Genentech USA, Inc.’s Avastin (bevacizumab) is the least expensive option within the class. It has undergone clinical trials supporting its use in eye disorders, but Genentech has not applied for approval of the indications. For ocular use, it costs about $50 per injection compared with around $1,500 to $2,000 for the other treatments.

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  • Angela Maas

    Angela has an extensive background of editing, reporting and writing for trade and consumer publications. She has written Radar on Specialty Pharmacy since she joined AIS Health in 2005 and has broad knowledge of the various issues at play within the space. She also has written for Spotlight on Market Access since its 2017 launch. Before joining AIS Health, she was managing editor at Employee Benefit News and Employee Benefit News Canada and managing editor at Hem Aware (a hemophilia publication), Lupus Living and Momentum (a multiple sclerosis publication). She has a B.A. in English and an M.A. in British literature from Arizona State University.

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