Eylea Biosimilar Pavblu Enters Crowded Market With Some Uncertainty
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Nov 14, 2024
The first biosimilar of Regeneron Pharmaceuticals, Inc.’s Eylea (aflibercept) recently hit the U.S. market when Amgen Inc. launched Pavblu (aflibercept-ayyh). The drug is entering a crowded class that includes a compounded drug used off-label, as well as a high-dose formulation of Eylea. But it’s unclear how much both agents may be used going forward.
A compounded formulation of Roche Group unit Genentech USA, Inc.’s Avastin (bevacizumab) is the least expensive option within the class. It has undergone clinical trials supporting its use in eye disorders, but Genentech has not applied for approval of the indications. For ocular use, it costs about $50 per injection compared with around $1,500 to $2,000 for the other treatments.
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